Lineage distribution of SARS-CoV-2 across geographic regions of Ontario, Canada, Western New York, and New York City over time |
Abstract:
The COVID-19 pandemic has prompted an unprecedented global effort to understand and mitigate the spread of the SARS-CoV-2 virus. In this study, we present a comprehensive analysis of COVID-19 in Western New York (WNY), integrating individual patient-level genomic sequencing data with a spatially informed agent-based disease Susceptible-Exposed-Infectious-Recovered (SEIR) computational model. The integration of genomic and spatial data enables a multi-faceted exploration of the factors influencing the transmission patterns of COVID-19, including genetic variations in the viral genomes, population density, and movement dynamics in New York State (NYS). Our genomic analyses provide insights into the genetic heterogeneity of SARS-CoV-2 within a single lineage, at region-specific resolutions, while our population analyses provide models for SARS-CoV-2 lineage transmission. Together, our findings shed light on localized dynamics of the pandemic, revealing potential cross-county transmission networks. This interdisciplinary approach, bridging genomics and spatial modeling, contributes to a more comprehensive understanding of COVID-19 dynamics. The results of this study have implications for future public health strategies, including guiding targeted interventions and resource allocations to control the spread of similar viruses.
Commuter behavior dynamics in WNY. Estimated commuter populations originating in a specific county. (A) Commuter behavior with Erie County origins. (B) Commuter behavior from Niagara County origin. (C) Commuter behavior from Monroe County origin. (D) Composite Commuter behavior network. |
Full Reference:
Bard, J.E., Jiang, N., Emerson, J., Bartz, M., Lamb, N.A., Marzullo, B.J., Pohlman, A., Boccolucci, A., Nowak, N.J., Yergeau, D.A., Crooks, A.T. and Surtees, J. (2024), Genomic Profiling and Spatial SEIR Modeling of COVID-19 Transmission in Western New York, Frontiers in Microbiology, 15. Available at https://doi.org/10.3389/fmicb.2024.1416580 (pdf)